Author

Shuhui Wang Lorkowski

Cleveland ClinicORCID 0009-0006-7206-5243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jonathan D. SmithiD· 2 shared Alexander M. Alzayed· 1 shared Annette BellariD· 1 shared Anthony J. HorakiD· 1 shared Brian Ritchey· 1 shared C. Alicia TraughberiD· 1 shared Daniela S. AllendeiD· 1 shared David W. StreemiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Jonathan D. SmithORCID

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2 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedDec 27, 2023

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury

Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey…·Jonathan Mark Brown

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.

9 citations

mousestatistical model

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GeneticsScientific ReportsPeer-reviewedMay 13, 2021

QTL analysis of macrophages from an AKR/JxDBA/2J intercross identified the Gpnmb gene as a modifier of lysosome function

Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski…·Jonathan D. Smith

This study identifies Gpnmb as a modifier of lysosome function in macrophages using QTL analysis in an AKR/JxDBA/2J intercross, showing its impact on proteolysis but not cholesterol metabolism.

23 citations

mousebulk RNA-seq

𝕏 PostBluesky