Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy
Jeremy Y. Huang, Brian Freed, Martin Hanus, Kelly Keefe, Ming Sum Ruby Chiang, Alexander Brezzani, Yongyi Luo, Yihang Li, Becky Lam, Stephanie Holley, Joseph Gans, Zuzana Dostalova, Buyun Tang, Clifford G. Phaneuf, Erin A. Teeple, , Can Kayatekin
The paper inhibits Elovl1 in a mouse model of ALD to reduce VLCFA accumulation, finding it corrects lipid pathways but also causes unexpected transcriptional changes.
iScience · Jul 31, 2025Peer-reviewedPharmacology & Toxicology