Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct origin
Nikita M. Shepelev, Elizaveta A. Razumova, Alexandr I Lavrov, Stephen J. Kiniry, Alexandr Makaryuk, Renata Bibisheva, О. А. Донцова, Pavel V. Baranov, Maria P. Rubtsova
The paper identifies essential uORFs for cell proliferation in human cell lines and shows their regulatory role through cis-elements and variant disruption.
bioRxiv · Jul 7, 2025 · PreprintMolecular Biology