Chemical inhibition of SUMOylation activates the FSHD locus
Alice Nordlinger, Loéva Morin, Alexandra Andrieux, Jean Philippe Trani, Pierre Perrin, Nathalie Eudes, Anne Bigot, Anne Dejean, Frédérique Magdinier
The paper shows that inhibiting SUMOylation with TAK981 increases DUX4 expression in human muscle cells without affecting DNA methylation or SMCHD1 activity, suggesting a new therapeutic approach for FSHD.
Scientific Reports · Jan 9, 2026Peer-reviewedGenetics