GeneticsScientific ReportsPeer-reviewed
Chemical inhibition of SUMOylation activates the FSHD locus
Alice Nordlinger, Loéva Morin, Alexandra Andrieux…·Frédérique Magdinier
The paper shows that inhibiting SUMOylation with TAK981 increases DUX4 expression in human muscle cells without affecting DNA methylation or SMCHD1 activity, suggesting a new therapeutic approach for FSHD.
DOI 10.1038/s41598-025-33624-0