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Alexandra Johnson

New York University

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Neuroscience· 1

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Approach:experimental assay· 1

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Arjun V. MasurkariD· 1 shared Chengju Tian· 1 shared Isabel Reyes· 1 shared

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Impact of dendritic spine loss on excitability of hippocampal CA1 pyramidal neurons: a computational study of early Alzheimer disease

Chengju Tian, Isabel Reyes, Alexandra Johnson, Arjun V. Masurkar

This study uses computational models to show that dendritic spine loss in hippocampal CA1 neurons increases synaptic input boosting, affecting excitability and synaptic integration in early Alzheimer's disease.

Hippocampus · Aug 13, 2025Peer-reviewedNeuroscience