Hyaluronan and CD44 targeting reverses early matrix changes, proinflammatory signals and fibrosis in primary sclerosing cholangitis
Vidushi Bansal, Lóránd Váncza, Weiguo Fan, Koshi Kunimoto, Tzu Han Lo, Nhu Nguyen, Andrew Richardson, Antonios Chronopoulos, Rui Chen, Xingcai Zhang, Alexandre de Fraipont, Yuan Li, Yi Wei, Gregory W. Charville, Shuang Li, , Natalie Julia Torok
This study identifies HA and CD44 as mediators of matrix changes and fibrosis in PSC, showing their targeting can reverse disease progression.
bioRxiv · Jul 24, 2026 · PreprintPathology