Pervasive translation of the downstream ORF from bicistronic mRNAs by human cells: impact of the upstream ORF codon usage and splicing
Philippe Paget‐Bailly, Alexandre Helpiquet, Mathilde Decourcelle, Roxane Bories, Ignacio G. Bravo
This study demonstrates that human cells can translate downstream ORFs in bicistronic mRNAs, showing that upstream ORF codon usage and splicing affect downstream translation efficiency.
Protein Science · Jan 22, 2025Peer-reviewedMolecular Biology