Lactate is a major energy substrate for cortical neurons and enhances their firing activity.
Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, H Geoffroy, Régine Hepp, Jérémie Naudé, Benjamin Le Gac, Richard Egger, Bertrand Lambolez, Dongdong Li, Jean Rossier, Jochen F. Staiger, Hiromi Imamura, , Bruno Cauli
The paper shows lactate enhances cortical neuron spiking activity through KATP channels and is preferentially used as an energy substrate over glucose.
eLife · Nov 11, 2021Peer-reviewedNeuroscience