Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence
Alexandre Nadeau, Marike Ouellet, Raphaël Béland, Clément Mercier, Stéphanie Robillard, Farah Lizotte, Marc‐Antoine Despatis, C. Florian Bentzinger, Pedro Geraldes
This paper shows that deleting SHP-1 in endothelial cells improves blood flow and limb function in diabetic mice by reversing senescence and restoring VEGF activity.
Journal of Molecular and Cellular Cardiology · Mar 9, 2025Peer-reviewedCell Biology