Narges Abdian

This study shows that glucosylceramide-induced ectosomes transmit pathogenic α-synuclein between neurons in Parkinson's disease.

This study investigates how LRRK2 kinase activity affects GCase activity in microglia under inflammatory conditions, finding that LRRK2 variants influence GCase response to interferon gamma.

The paper identifies MLN4924 as a compound that improves cell viability in TDP-43 mutant motor neurons by targeting NEDD8-activating enzyme.

This study uses 3D iPSC-derived motor neuron spheroids with SOD1 mutations to show ALS-related phenotypes and genetic variability effects.

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

This study shows that homozygous ALS-linked TARDBP mutations cause synaptic abnormalities and reduced activity in human iPSC-derived motor neurons without affecting TDP-43 localization or aggregation.

This study compares FMR1 knock-out and Fragile X patient iPSC-derived neuronal models, finding shared transcriptional and functional impairments in neuronal activity and differentiation.

The paper generates PRKN and PINK1-KO and double KO human iPSC lines using CRISPR/Cas9 to model Parkinson's disease.

Auto-qPCR automates qPCR data analysis, reducing errors and time by providing a web-based tool for DNA quantification and gene expression analysis.

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.

This study introduces a streamlined CRISPR workflow to generate isogenic iPSCs with specific ALS-related mutations for modeling the disease.