Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
Alexia Kirby, Cian Ward, Clara S. Goulet, Nicholas D. Calvert, Ryan Daniel, Joseph Wai-Hin Leung, Ashwin Sharma, Mojmír Suchý, Cassandra Donatelli, Jing Wang, Emily Standen, Adam J. Shuhendler
This study develops a CEST-MRI contrast agent to detect aldehydes in mTBI, showing increased aldehyde levels and neuroinflammation in mice with ALDH2 deficiency.
bioRxiv · Apr 16, 2024Biochemistry