NeurosciencebioRxivPreprint
Dysregulation of energy metabolism and calcium homeostasis in iPSC-derived neurons carrying Presenilin-1 M146L gene mutation
Carlos Wilson, Pablo Galeano, María Mónica Remedi…·Laura Morelli
This study examines iPSC-derived neurons with a PS1M146L mutation, finding altered calcium dynamics, increased mitochondrial respiration, and ROS levels, suggesting impaired calcium homeostasis under stress.
DOI 10.1101/2025.09.08.674945