Dysregulation of energy metabolism and calcium homeostasis in iPSC-derived neurons carrying Presenilin-1 M146L gene mutation
Carlos Wilson, Pablo Galeano, María Mónica Remedi, Gisela V Novack, Lorenzo Campanelli, Laura Gastaldi, Esteban Miglietta, Andrés H. Rossi, Natividad Olivar, Luis I Brusco, Eduardo M Castaño, Alfredo Cáceres, Laura Morelli
This study examines iPSC-derived neurons with a PS1M146L mutation, finding altered calcium dynamics, increased mitochondrial respiration, and ROS levels, suggesting impaired calcium homeostasis under stress.
bioRxiv · Sep 8, 2025 · PreprintNeuroscience