Laura Morelli

Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.

This study examines iPSC-derived neurons with a PS1M146L mutation, finding altered calcium dynamics, increased mitochondrial respiration, and ROS levels, suggesting impaired calcium homeostasis under stress.

This study conducts the first GWAS on Alzheimer's disease in South American populations, identifying shared genetic risk factors with European populations.