A Chemical-mechanical Coupled Model Predicts Roles of Spatial Distribution of Morphogen in Maintaining Tissue Growth
Alireza Ramezani, Samuel R. Britton, Roya Zandi, Mark Alber, Ali Netmatbakhsh, Weitao Chen
The paper develops a multiscale chemical-mechanical model to study how the spatial distribution of the Dpp morphogen affects tissue growth in Drosophila wing discs, showing that a larger gradient domain leads to increased size, faster growth, and more symmetric shape.
bioRxiv · Jun 28, 2022 · PreprintDevelopmental Biology