Nav1.5 regulates intrinsic cardiac neuronal excitability and expands the cellular basis of SCN5A channelopathies
Alice Jean, Hanitriniaina Rabeony, Christophe Magaud, Michael Derangeon, Agnès Tessier, Barnabas Gellen, Jean-Francois Faivre, Flavien Charpentier, Aurélien Chatelier
This study shows Nav1.5 is expressed in intrinsic cardiac neurons and affects their excitability, expanding the understanding of SCN5A channelopathies beyond cardiomyocytes.
bioRxiv · Oct 7, 2026 · PreprintPhysiology