Flavien Charpentier

This paper demonstrates wireless photoactivation of a peptide to modulate cardiac excitability in vivo using an implantable device.

This study shows Nav1.5 is expressed in intrinsic cardiac neurons and affects their excitability, expanding the understanding of SCN5A channelopathies beyond cardiomyocytes.

This study investigates the pathogenic effects of the DES p.R406W mutation, showing it causes electrical and structural heart remodeling linked to arrhythmias and sudden cardiac death.

MeTAL links KCNH2 variant biophysical properties to ECG phenotypes, revealing nonlinear relationships and improving risk prediction for inherited arrhythmia syndromes.

This study shows that AaH-II selectively activates TTX-S Nav channels, inducing arrhythmias in cardiac tissue, and suggests targeting these channels as an antiarrhythmic strategy.

The paper uses Drosophila to test if genes near BrS risk loci affect cardiac function, identifying potential candidates for further study.

This paper demonstrates that overexpressing the N-terminal fragment of Nav1.5 restores cardiac sodium current and electrical activity in models of Brugada syndrome.