Enriched Methylomes of Low-input and Fragmented DNA Using Fragment Ligation EXclusive Methylation Sequencing (FLEXseq)
Jingru Yu, Lauren S. Ahmann, Yvette Y. Yao, Angus Martin Shaw Toland, Alicia Snowden, Chandler C. Ho, Netanel Loyfer, Tommy Kaplan, Hannes S. Vogel, Linlin Wang, Brooke E. Howitt, Brittany Holmes, Alarice Cheng-Yi Lowe, Wei Gu
The paper introduces FLEXseq, a methylation sequencing method that enriches and sequences DNA fragments flanking the CCGG motif, showing strong correlation with WGBS and potential for diagnostic applications.
Nucleic Acids Research · Apr 16, 2026Peer-reviewedGenomics