GenomicsNucleic Acids ResearchPeer-reviewed
Enriched Methylomes of Low-input and Fragmented DNA Using Fragment Ligation EXclusive Methylation Sequencing (FLEXseq)
Jingru Yu, Lauren S. Ahmann, Yvette Y. Yao…·Wei Gu
The paper introduces FLEXseq, a methylation sequencing method that enriches and sequences DNA fragments flanking the CCGG motif, showing strong correlation with WGBS and potential for diagnostic applications.