First O-demethylation activity in Arabidopsis specialized metabolism resolves the missing step in esculetin biosynthesis
Alicja Dobek, Clément Charles, Izabela Perkowska, Ryosuke Munakata, Jérémy Grosjean, Alain Hehn, Ewa Łojkowska, Anna Ihnatowicz, Alexandre Olry
The paper identifies the first O-demethylation reaction in Arabidopsis specialized metabolism, resolving the missing step in esculetin biosynthesis and showing its role in iron acquisition.
bioRxiv · Jul 13, 2026 · PreprintPlant Biology