Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Eduard H.T.M. Ebberink, Evolène Deslignière, Alisa Ruisinger, Markus Nuebel, Marco Thomann, Albert J. R. Heck
This paper develops a protocol to accurately measure the mass of large DNA plasmids using mass photometry by converting dsDNA to ssDNA-like particles, achieving mass accuracy within 1-3%.
Molecular Therapy — Nucleic Acids · Jul 17, 2025Peer-reviewedBiochemistry