Microbiome-derived Short Chain Fatty Acids modulate microglial inflammatory responses in a sex- and metabolite-specific manner
Morgan Towriss, Vivien Dang, Jenna Goeres, Jatin Choudhary, Alison Aube, Juliana Montoya Sanchez, Clianta Anindya, Koyah Morgan-Banke, Jordan E. Hamden, Christopher Whidbey, Annie Vogel Ciernia
This study shows SCFAs modulate microglial inflammation differently in males and females, with butyrate strongly affecting gene expression and histone acetylation.
bioRxiv · Jul 4, 2026 · PreprintNeuroscience