Annie Vogel Ciernia

This study shows that female sex and APOEe4 genotype differentially affect microglial transcriptomic profiles in the hippocampus and cortex of mice.

This study shows SCFAs modulate microglial inflammation differently in males and females, with butyrate strongly affecting gene expression and histone acetylation.

The paper integrates microglia morphology and gene expression using spatial transcriptomics and proteogenomics to identify morphology-related genes in the human brain.

ROIMAPer is an open-source FIJI plugin for registering brain images to standard atlases, demonstrating accuracy in quantifying marker genes across brain regions and subregions.

This study investigates how early-life gut inflammation affects microbiome, endocrine, and behavioral outcomes, revealing sex-specific impacts on microbiota composition, hormone levels, and behavior.

This study surveys Canadian early-career health researchers to assess pandemic impacts, revealing high burnout rates and mental health declines.

This study shows that repeated LPS exposure induces training and tolerance in microglial responses across brain regions, with distinct gene expression patterns and morphological changes.

The paper develops an open-source pipeline to characterize microglia morphology at single-cell resolution using ImageJ and R, identifying distinct morphological states across brain regions and conditions.

This study shows that inhibiting Hdac3 enhances microglial neuroprotective functions and gene expression responses to inflammation.

MGEnrichment provides a web tool for analyzing gene expression data against curated microglia gene lists to assess enrichment and relevance in neuro-immunology research.

The paper shows BTBR mouse genetic variants lead to altered chromatin accessibility and hyper-responsive innate immunity in macrophages, linking genetic differences to ASD-related immune abnormalities.

The paper identifies epigenomic signatures in NDD cortex samples, revealing shared regulatory functions and enrichment for genetic risk factors across different NDD types.

The paper identifies 3,152 differentially methylated regions in DS brain tissue using WGBS, revealing hypermethylation in key biological pathways and cross-tissue concordance for hypermethylated regions.

This study shows that MeCP2-e1 mutation in mice reproduces motor and metabolic issues seen in Rett syndrome patients.

This study identifies Snord116-dependent diurnal DNA methylation rhythms in mouse cortex and shows their disruption in Prader-Willi syndrome.

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.

The paper investigates how augmented maternal care affects DNA methylation, gene expression, and miRNA levels in the developing hypothalamus, identifying genes linked to stress resilience.

The paper investigates epigenomic and transcriptomic changes in microglia from offspring of dams with allergic asthma, finding links to autism-related gene dysregulation.