Bacterial Hsp90 promotes virulence factor production through maintenance of NRPS megaenzymes
Alison Fratacci, Amine Ali Chaouche, Marie Corteggiani, Flora Ambre Honoré, Manel Khelil Berbar, Nadège Bossuet‐Greif, Sébastien Dementin, Sophie Bleves, Maya Belghazi, Régine Lebrun, Jean‐Philippe Nougayrède, Éric Oswald, Bérengère Ize, Olivier Genest
This study shows bacterial Hsp90 stabilizes megasynthases required for virulence factor production in E. coli and P. aeruginosa.
bioRxiv · Jul 1, 2025 · PreprintMicrobiology