Sophie Bleves

The Type VI secretion effector TpeX expands the pore-forming virulence arsenal of Pseudomonas aeruginosa

This study identifies TpeX as a pore-forming T6SS effector in P. aeruginosa that disrupts bacterial membranes, with its activity regulated by an immunity protein.

Molecular Insights into the bactericidal Toxin Tle1 of Pseudomonas aeruginosa: Interaction with VgrG, its adaptor, and immunity protein

This study characterizes Tle1, a bactericidal toxin from Pseudomonas aeruginosa, and identifies its interactions with VgrG4a, Tla1, and Tli1a, revealing the molecular mechanisms of its delivery and inhibition.

Bacterial Hsp90 promotes virulence factor production through maintenance of NRPS megaenzymes

This study shows bacterial Hsp90 stabilizes megasynthases required for virulence factor production in E. coli and P. aeruginosa.