Examining chromatin heterogeneity through PacBio long-read sequencing of M.EcoGII methylated genomes: an m6A detection efficiency and calling bias correcting pipeline
Allison F. Dennis, Zhuwei Xu, David J. Clark
The paper develops a pipeline to correct m6A detection biases in PacBio long-read sequencing of M.EcoGII-treated yeast nuclei, revealing chromatin heterogeneity at the single-molecule level.
Nucleic Acids Research · Apr 4, 2024Peer-reviewedGenomics