Zhuwei Xu

The paper uses long-read sequencing to analyze DNA methylation patterns in SDHx-deficient PPGLs and finds global hypomethylation with focal hypermethylation at specific CpG islands.

The paper shows that chromatin in living S. pombe cells is generally accessible, challenging the idea that heterochromatin represses DNA access.

The paper shows Sir proteins impede but do not prevent access to silent chromatin in yeast, using DNA methylation rates as a measure.

The paper assesses the roles of ISW1 and CHD1 chromatin remodelers in suppressing nucleosome dynamics in living yeast cells, finding that their depletion increases DNA methylation rates.

The paper measures genome accessibility in living human cells and finds that heterochromatin is more accessible than previously thought due to dynamic nucleosome behavior.

The paper develops a pipeline to correct m6A detection biases in PacBio long-read sequencing of M.EcoGII-treated yeast nuclei, revealing chromatin heterogeneity at the single-molecule level.

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

This study identifies new genes and mechanisms regulating fluconazole resistance in C. glabrata, showing Pdr1 senses cellular stress rather than directly responding to antifungals.