One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa / CD16a structure
Paul G Kremer, Elizabeth A Lampros, Allison M Blocker, Adam W. Barb
This study identifies an N-glycan at position N162 that enhances FcγRIIIa/CD16a antibody-binding affinity and NK cell ADCC by stabilizing the FG loop structure.
bioRxiv · Jun 17, 2024Immunology