Insulin enhances presynaptic glutamate release via opioid receptor-mediated disinhibition
Tracy L. Fetterly, Max F. Oginsky, Allison M. Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R. Ferrario
This study shows insulin enhances presynaptic glutamate release in the nucleus accumbens via opioid receptor-mediated disinhibition, while IGF receptor activation decreases it, with obesity impairing insulin receptor function.
bioRxiv · Sep 1, 2020 · PreprintNeuroscience