Genetic incorporation of diverse non-canonical amino acids for histidine substitution
Anton Natter Perdiguero, Sandro Fischer, Alrika Ruth Lischke, Benjamin P Manser, Alexandria Deliz Liang
This paper develops nine new aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode 12 histidine-like non-canonical amino acids for enzyme engineering and catalytic studies.
Journal of the American Chemical Society · Mar 26, 2026Peer-reviewedSynthetic Biology