Author

Sandro Fischer

University of ZurichORCID 0000-0002-0015-9084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Organism:bacteria (other)· 1 Assay:protein sequence· 1

Frequent Co-Authors

Alexandria Deliz LiangiD· 2 shared Anton Natter PerdigueroiD· 2 shared Alrika Ruth Lischke· 1 shared Benjamin P ManseriD· 1 shared Kelvin LauiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersSynthetic Biology

Alexandria Deliz LiangORCID

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2 papers

Recent·Most cited

Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme

Sandro Fischer, Anton Natter Perdiguero, Kelvin Lau, Alexandria Deliz Liang

This study introduces a method to engineer hydrophobicity in a bacterial laccase using non-canonical amino acids, resulting in improved catalytic activity.

Nature Chemistry · Apr 13, 2026Peer-reviewedSynthetic Biology

Genetic incorporation of diverse non-canonical amino acids for histidine substitution

Anton Natter Perdiguero, Sandro Fischer, Alrika Ruth Lischke, Benjamin P Manser, Alexandria Deliz Liang

This paper develops nine new aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode 12 histidine-like non-canonical amino acids for enzyme engineering and catalytic studies.

Journal of the American Chemical Society · Mar 26, 2026Peer-reviewedSynthetic Biology