Striatal cell-type-specific encoding stability and reorganization for goal-directed behavior and habit
Melissa Malvaez, Alvina Liang, Baila S. Hall, Jacqueline R. Giovanniello, Natalie Paredes, Jorge A. González, Garrett J. Blair, Ana C. Sias, Michael D. Murphy, Wanyi Guo, Alicia Wang, Malika Singh, Nicholas K. Griffin, Samuel P. Bridges, Anna J. Wiener, , Kate M. Wassum
The paper tracks and manipulates striatal neuron activity during goal-directed learning and habit formation, finding D1+ neurons maintain stable action representations while A2A+ neurons show transient or slow reorganization.
bioRxiv · Jan 26, 2025 · PreprintNeuroscience