Michael D. Murphy

The paper investigates sex-specific regulation of hippocampal Cdk5 in mice under different stress paradigms, finding male-specific changes in mRNA and protein levels under combined stress conditions.

This study shows corticosterone reduces DMS synaptic plasticity genes and increases DLS ones, linking stress hormone effects to behavioral inflexibility in mice.

The paper tracks and manipulates striatal neuron activity during goal-directed learning and habit formation, finding D1+ neurons maintain stable action representations while A2A+ neurons show transient or slow reorganization.

The paper identifies distinct cortical-amygdala projections that separately encode and retrieve reward value, revealing a new circuit for reward valuation and pursuit.

This study shows that HDAC3 negatively regulates habit formation in the dorsal striatum, with distinct roles in the dorsolateral and dorsomedial striatum.