Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in Chronic Kidney Disorder induced Vascular Calcification.
Shivani Arora, Gregory Halsey, Fatema Tuj Zohora, Alyssa Swiss, Naren R. Vyavahare
This study shows targeted chelation therapy with EDTA-NP reduces senescent cells and NLRP3 expression in calcified aortas of CKD models.
International Journal of Immunopathology and Pharmacology · Dec 1, 2025Peer-reviewedPharmacology & Toxicology