Naren R. Vyavahare

Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in Chronic Kidney Disorder induced Vascular Calcification.

This study shows targeted chelation therapy with EDTA-NP reduces senescent cells and NLRP3 expression in calcified aortas of CKD models.

Smooth Muscle Cell-Specific TGFβ2 Protects Against Thoracic Aortic Aneurysm and Dissection in Mice

This study shows that TGFβ2 from vascular smooth muscle cells is essential for aortic wall integrity, and its loss leads to aneurysms and dissection in mice.