Energy scarcity and impaired mitochondrial translation induce perinuclear stress granule clustering
Uxoa Fernandez-Pelayo, Mikel Muñoz-Oreja, Marina Villar-Fernandez, Amaia Lopez de Arbina, Irati Aiestaran-Zelaia, María Jesús Sánchez-Guisado, Boris Pantic, Amaia Elicegui, Monica Zufiria, Pablo Iruzubieta, Maialen Sagartzazu-Aizpurua, Jesús M. Aizpurua, Matthew Gegg, Sonia Alonso-Martin, Jesus Ruiz-Cabello, , Ian James Holt
The paper shows that energy scarcity and mitochondrial translation impairment cause ALS-FTD-related proteins to form perinuclear stress granule clusters, potentially leading to pathological inclusions.
bioRxiv · Feb 1, 2024 · PreprintCell Biology