H3K27me3 Drives Constricted Migration Induced 3D Genome Rewiring in Melanoma
Taiwo Habeeb Olajide, Muhammad Adeyemi Ajagbe, Alvaro Rodriguez Gonzalez, Hameed Ijadunola, Chandler Ross, Lily Eisenklam, Amanda Swets, Rachel Patton McCord
This study shows that H3K27me3 modification drives 3D genome changes in melanoma cells after constricted migration, affecting migration efficiency and chromatin compartment switching.
bioRxiv · Sep 14, 2026 · PreprintGenomics