Circular DNA interacts with Cathelicidin LL37 to efficiently activate plasmacytoid dendritic cells
Amara Ejikemeuwa, Jia He, Yuangao Wang, Guangming Li, Weirong Yuan, Wuyuan Lu, Lishan Su
The paper shows circular DNA activates plasmacytoid dendritic cells, and LL37 enhances this activation through TLR9, highlighting DNA topology's role in immune sensing.
bioRxiv · Oct 21, 2026 · PreprintImmunology