Lishan Su

HEPLISAV-B vaccine breaks HBV immune tolerance in a mouse model, inducing HBsAg clearance and anti-HBs immunity through CD4 T cell-dependent mechanisms.

The paper shows circular DNA activates plasmacytoid dendritic cells, and LL37 enhances this activation through TLR9, highlighting DNA topology's role in immune sensing.

This study shows PML suppresses HBV cccDNA transcription via SUMOylation and SMC5/6-dependent mechanisms, with HBx modulating this interaction.

This study shows CD24-Fc reduces inflammation and rescues CD8 T cell function in HIV-1 infected individuals on cART.

TWO-SIGMA-G tests gene sets in scRNA-seq data by accounting for gene and cell correlations, showing improved power and error control in simulations and real datasets.

This study shows that the bromodomain inhibitor I-BET151 activates HIV-1 transcription in monocytic cells but not CD4+ T cells under cART in humanized mice.