Ritonavir-Induced Cellular Stress Alters Viral HBs Glycoprotein Biogenesis and Production of Infectious Hepatitis D Virions
Walid El Orch, Clémence Jacquemin, Florentin Pastor, Romain Barnault, Fanny Charriaud, Amaury Wuilbaut, Clement Nabaile, Clementine Deleuze, Margaux Michel, Hiroshi Kadokura, Massimiliano Gaetani, Margot BEGUE, Eric A. Richard, Camille Sureau, Bernard Verrier, , Pierre‐Olivier Vidalain
This paper shows ritonavir and other cytochrome P450 inhibitors reduce infectious HDV virion production by inducing oxidative stress and disrupting HBs glycoprotein biogenesis in human hepatocytes.
bioRxiv · Mar 23, 2026 · PreprintMicrobiology