Nociceptor-restricted cannabinoid receptor 1 contributes to chronic but not acute analgesia
Amber L. Milligan, Audrey R Green, Katherine M. Garner, Thomas A. Szabo-Pardi, Luz R. Barron, Dana M. Jenkins, Carlos M. Castorena, Joel Keith Elmquist, Michael D. Burton
The paper investigates the role of cannabinoid receptor 1 (CB1R) in pain modulation by selectively reactivating it in peripheral sensory neurons, finding it contributes to chronic but not acute analgesia.
bioRxiv · Aug 21, 2026 · PreprintNeuroscience