Carlos M. Castorena

Nociceptor-restricted cannabinoid receptor 1 contributes to chronic but not acute analgesia

The paper investigates the role of cannabinoid receptor 1 (CB1R) in pain modulation by selectively reactivating it in peripheral sensory neurons, finding it contributes to chronic but not acute analgesia.

Adrβ2 in skeletal muscle cells is required for exercise-induced Pgc1α but not for metabolic benefits of exercise on diet-induced obesity

Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia

This study shows that increasing 2-AG levels reduces opioid reward but not analgesia in mice, suggesting a potential therapeutic strategy for pain treatment.

Asleep at the Wheel: Forward Genetic ENU Mutagenesis Screen for Mouse Models of Chronic Fatigue Identifies a Mutation in Slc2a4 (GLUT4)

The paper identifies a mutation in Slc2a4 (GLUT4) in mice that causes chronic fatigue-like behaviors through a forward genetic screen.