The Pemphigus Vulgaris antigen desmoglein-3 suppresses p53 function via the YAP-Hippo pathway
Ambreen Rehman, Yang Cai, Christian Hünefeld, Hana Jedličková, Yunying Huang, M Teck Teh, Jutamas Uttagomol, Angray Kang, Gary Warnes, Usama Ahmad, Catherine Harwood, Daniele Bergamaschi, Eric Kenneth Parkinson, Martin Röcken, Ian Hart, Hong Wan
This study shows Dsg3 suppresses p53 function through the YAP-Hippo pathway, contributing to PV pathology by affecting skin homeostasis.
bioRxiv · Aug 25, 2018 · PreprintCell Biology