Macropinocytosis mediates neurotropism of Cryptococcus neoformans in a human organoid model of the blood-brain barrier.
Amelia B. Bennett, Dylan M Lanser, Kiem Vu, Amita Rani Sahoo, Matthias Buck, Angie Gelli
This study identifies macropinocytosis as the mechanism by which Cryptococcus neoformans enters brain endothelial cells via a CD44-EphA2 complex in a human BBB organoid model.
Communications Biology · Jul 7, 2026Peer-reviewedMolecular Biology