Amita Rani Sahoo

Host membrane cholesterol constrains constitutive signaling of the oncogenic KSHV GPCR ORF74

This study identifies a cholesterol-dependent mechanism by which the KSHV GPCR ORF74 regulates its constitutive activity through structural and functional analysis.

Molecular Determinants of Receptor-Specific Membrane Interactions in EphA1 and EphA2 from Coarse-Grained Simulations

This study uses coarse-grained simulations to show how TM and TM-proximal domains of EphA1 and EphA2 differ in dimerization and lipid interactions, explaining their distinct activation behaviors.

A model for PIP2/3 and Rnd1 effects on Plexin-B1 GAP activity on Rap1b GTPase derived from molecular dynamics simulations

This study uses molecular dynamics simulations to investigate how PIP2/3 and Rnd1 affect Plexin-B1 GAP activity on Rap1b GTPase, revealing lipid-dependent structural and functional changes.

Macropinocytosis mediates neurotropism of Cryptococcus neoformans in a human organoid model of the blood-brain barrier.

This study identifies macropinocytosis as the mechanism by which Cryptococcus neoformans enters brain endothelial cells via a CD44-EphA2 complex in a human BBB organoid model.

Tyrosine phosphorylation and the inhibitory C-terminal SAM domain moderately affect transient interactions in a EphA2 cytoplasmic fragment in solution: A combined experimental and molecular modeling study.

This study investigates the structural dynamics of the EphA2 intracellular fragment, showing phosphorylation affects transient interactions and signaling potential.

Computation model predicts Rho GTPase function with the Plexin Transmembrane receptor GAP activity on Rap1b via dynamic allosteric changes

The paper uses molecular dynamics simulations to analyze conformational changes in Plexin-B1 bound to Rap1b, Rnd1, and Rac1, revealing differences in dynamics and interactions.

Cholesterol inhibits oncogenic EphA2 activation

This study shows that cholesterol inhibits EphA2 self-assembly and oncogenic signaling by preventing its activation through an in-trans mechanism involving protein kinase A.

Cholesterol-Dependent Dimerization and Conformational Dynamics of EphA2 Receptors: Insights from Coarse-Grained and All-Atom Simulations

This study uses simulations to show cholesterol stabilizes EphA2 dimerization and TM-JM interactions with PIP2, highlighting membrane composition's role in EphA2 signaling and cancer progression.

Phosphatidylinositol (4,5)-bisphosphate drives the formation of EGFR and EphA2 complexes

This study uses PIE-FCCS to show that PIP2 enhances EGFR and EphA2 multimerization in live cells, revealing a role for anionic lipids in RTK interactions.