Comparative Effects of Hypoxic vs. Normoxic Mesenchymal Stem Cell-Derived Extracellular Vesicles on Tissue Repair Following Volumetric Muscle Loss (VML)
Avantika Jain, Amelia Ridolfo, Mathangi Mohankumar Subramanian, David L Johnson, Jacki Kornbluth, Koyal Garg
This study compares the effects of hypoxic and normoxic MSC-derived EVs on muscle repair after VML, finding that normoxic EVs promote better regeneration despite lower yield.
bioRxiv · Jan 2, 2026 · PreprintBioengineering