Author

Amesh K. Sarecha

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

John A. Zadroga· 2 shared Lale ÖzcaniD· 2 shared Stefano Spolitu· 2 shared Brea TinsleyiD· 1 shared Heena AgarwaliD· 1 shared Yating WangiD· 1 shared Yating WangiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

John A. Zadroga

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2 papers

Recent·Most cited

Geranylgeranyl Isoprenoids and Hepatic Rap1a Regulate Basal and Statin-Induced Expression of PCSK9

Yating Wang, Brea Tinsley, Stefano Spolitu, John A. Zadroga, Heena Agarwal, Amesh K. Sarecha, Lale Özcan

This study identifies geranylgeranyl isoprenoids and hepatic Rap1a as regulators of PCSK9 expression, showing that statin-induced PCSK9 is dependent on these factors and their inhibition reduces PCSK9 and plasma cholesterol.

Journal of Lipid Research · Feb 2, 2024Peer-reviewedMolecular Biology

Hepatocyte Rap1a Contributes To Obesity- and Statin-Associated Hyperglycemia

Yating Wang, Stefano Spolitu, John A. Zadroga, Amesh K. Sarecha, Lale Özcan

This study shows that Rap1a suppresses hepatic glucose production and that its inhibition, via statins, contributes to hyperglycemia in obesity.

Cell Reports · Aug 1, 2022Peer-reviewedMolecular Biology