The accumulation of orphan ribosomal proteins is a hallmark of ALS
Anabel Sáez-Mas, Guillermo de la Vega-Barranco, Amin El-Manchoud, Iván Ventoso, Sara Rodrigo, Vanesa Lafarga, Óscar Fernández-Capetillo
This study identifies the accumulation of orphan ribosomal proteins as a molecular hallmark of ALS, linking it to various ALS-related mutations and neurotoxins.
bioRxiv · May 19, 2026 · PreprintNeuroscience