Iván Ventoso

RiboCollSensor detects ribosome collisions in living cells with high sensitivity, showing real-time kinetics and stress response dynamics.

This study identifies the accumulation of orphan ribosomal proteins as a molecular hallmark of ALS, linking it to various ALS-related mutations and neurotoxins.

The paper identifies a chemical inducer of ribophagy, SALSa, that reduces toxicity of ALS-related arginine-rich peptides and extends lifespan in a Drosophila model.

This study investigates how SARS-CoV-2 NSP1 affects mRNA translation and stability, revealing that codon usage and 43S-PIC recruitment determine mRNA sensitivity to NSP1.

This study examines polysomal architecture changes in a mouse model of Huntington's disease, finding compacted polysomes and increased expression of ribosome stalling relief factors.

This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.

This study shows arginine-rich CPPs like (PR)n displace DNA- and RNA-binding factors, impairing nucleic acid processes and causing toxicity, similar to PROTAMINE's effects.